Considerations To Know About ceesdekker
Considerations To Know About ceesdekker
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Applying solitary-molecule optical and AFM imaging and power-spectroscopy techniques, we request to unravel the mechanistic areas of the construction and dynamics of chromosomes. Our research pursuits include things like:
1996, very first mesoscopic demand density waves devices; and 1st electrical measurements on only one metal nanocluster amongst nanoelectrodes
Multicolor imaging in the bacterial nucleoid and cell division proteins with blue, orange, and in the vicinity of-infrared fluorescent proteins
Given that 2000, Dekker has shifted the leading concentrate of his operate to biophysics exactly where he scientific tests the properties of single biomolecules and cells using the instruments of nanotechnology. This change of area was pushed by his fascination for that remarkable working of biological molecular constructions, in addition to through the very long-time period standpoint that many intriguing discoveries might be envisioned During this field.[5] Present traces of investigation in his biophysics team are while in the parts of:[six]
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The coiled-coil on the human Rad50 DNA restore protein incorporates unique segments of enhanced flexibility
Due to the fact 2000 he moved to solitary-molecule biophysics and nanobiology, with investigation from DNA supercoiling scientific studies of nucleosomes and DNA restore proteins to DNA translocation through nanopores. A short while ago his exploration has focused on studying mobile division with germs on chip, while his best curiosity is within the way of acknowledging synthetic cells.
Atomic drive microscopy shows that vaccinia topoisomerase IB generates filaments on DNA in the cooperative manner
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At this time, we also realized that it ought to be probable to employ only one semiconducting carbon nanotube to help make a transistor — and we established out to make it. We stretched personal semiconducting nanotubes across metallic electrodes and used the fundamental silicon substrate for a gate electrode, developing The fundamental three-terminal format of a field-outcome transistor (Fig.
Since 2000 he moved to solitary-molecule biophysics ceesdekker.net and nanobiology, with study from experiments of DNA loop extrusion and supercoiling to DNA translocation by way of nanopores. Much more recently his investigation has focused on finding out chromatin structure and mobile division with bacteria on chip, when he is additionally seeking to eventually build synthetic cells from The underside up.
Cees Dekker is Distinguished College Professor at TU Delft. Properly trained as a physicist, he pioneered nanotechnology with many discoveries on carbon nanotubes in the 1990s. Since 2000, he moved to single-molecule biophysics and nanobiology. His present exploration focuses on (i) nanopores for protein sequencing; (ii) chromosome structure, in particular SMC motor protein; and (iii) developing a dwelling artificial cell from lifeless molecules. Dekker is surely an elected member from the KNAW and fellow towards the APS and also the IOP.
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Illustration (two) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is revealed in grey, the rim of your pore is highlighted in crimson, and a 3D rendering on the movement on the DNA rod is exhibited.